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RNAI Libraries
RNAi Clone Library targeting
all annotated genes in the human and mouse genomes.
Background:
Recent work has identified that a conserved biological response to
double-stranded RNA, known as RNA interference (RNAi), specifically silences
protein-coding genes through degradation of homologous mRNAs. Scientists at Cold
Spring Harbor Laboratory (CSHL) have exploited this natural process to
efficiently and cost-effectively probe gene function through targeted RNAi-induction.
RNAi Clone Library:
Scientists in the Hannon Lab at CSHL are generating an RNAi Clone
Library consisting of at least 3 siRNAs specifically targeting every annotated
gene in the human and mouse genomes. By allowing for selective silencing of any
gene in the genome, these large-scale libraries of RNAi-inducing plasmids
provide a powerful tool for systematically probing gene function on a whole
genome scale and introduce novel methods to screen for potential therapeutic
targets associated with diseases ranging from HIV to cancer.
Greg Hannon is an expert in the areas of post-transcriptional gene silencing
and RNAi. His laboratory has been responsible for many of the seminal
discoveries that uncovered the role of RNAi in normal cell physiology. For a
more detailed explanation of RNAi and the potential of this technology please
refer to his most recent articles “Short hairpin RNAs (shRNAs) induce sequence-specific
silencing in mammalian cells.” (Genes Dev. 2002; 16, 948-958), “Germline
transmission of RNAi” (Nat Struct Biol. 2003; 10, 91-92) and “An epi-allelic
series of p53 hypomorphs created by stable RNAi produces distinct tumor
phenotypes in vivo.” (Nat Genet. 2003; 33, 396-400).
Applications:
The ability to generate RNAi-inducing clones individually target
specific genes in the human genome will permit rapid, cost-efficient, loss-of -function
genetic screens and rapid tests for genetic interactions to be performed in
mammalian cells. Such approaches hold tremendous promise for unleashing the
dormant potential of sequenced genomes and provide drug companies and individual
researchers with an efficient means to help locate gene targets involved in any
disease of interest.
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