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CacoReady Kit

A novel, ready-to-use system for in vitro intestinal absorption evaluations

Benefits

  • Differentiated Caco-2 barrier (21-day system), plated on HTS Transwell®-96 or HTS Transwell-24 permeable supports.
  • Integrated Transwells are to allow easier handling.
  • Proprietary conditioning medium allows up to 5 days of transportation/storage at room temperature.
  • User-friendly system and easy handling.
  • Cost-effective for any size laboratory.

Product Information

Product Number Product Name Format
001-1001 CacoReady 24-well Kit 24-well plate
001-1002 CacoReady 96-well Kit 96-well plate

CACOREADY 96-WELL PLATE

Product information

product name CACOREADY 96-WELL PLATE
description The CacoReady system is an integral tool designed to optimize time and costs for intestinal absorption evaluation of compounds. The kit has been designed to provide a user-friendly and suitable tool for high-throughput automated procedures. It provides users with the differentiated Caco-2 barrier (21-day system), plated on 24- or 96-Transwell plates.
description  
size 1 PLATE
shipment Room Temperature

Price (excl. VAT)

EUR 1900.00
GBP 1809.00

 

 

 

 

 

 

 

Technical description of the product (1 of 2)

The CacoReady™ kit contains:

  • 24-transwell HTS plate(s) with plated caco-2 cells
  • Technical sheet (Brief description of the kit, Quality control, Instructions for use)

Applications

  • Oral absorption efficiency
  • Compound screening
  • Oral bioavailability
  • Oral toxicity
  • Mechanisms for oral/intestinal absorption
  • Research on new delivery systems
  • Others

Description

The kit provides 14-day polarized cultures of Caco-2 cells on polycarbonate microporous filters in plates of 24 HTS transwells of 6.5 mm diameter, 0.33 cm2 area and 0.4 µm of pore diameter (fig. A).

An innovative conditioning media mantains the properties of the barrier, allowing us to provide customers with a robust screening tool. Figure B shows confocal analysis of occludin staining revealing tight junctions status in CacoReady™ cell barrier.

 

Apparent permeability coefficient of standard compounds

Characterization

BIOSAFETY: This product contains cell lines from human origin and must be handled as element of biological risk - For research use only

Reference CacoReady™
Batch number  
Transepithelial Electrical Resistance (Ohm.cm2)  
Lucifer yellow paracellular flux (%)  
Apparent permeability (cm/min)  
Preparation date  
Expires  

This table will be completed for each batch with corresponding data before sending.

 

 

 

Main advantages of the CacoReady™ kit

After a preliminar market research, and taking into account all available technical data,
ADVANCELL’s CacoReady™ kit represents an important innovation for drug discovery
researchers, dealing with intestinal absorption evaluation.

  • Cacoready ™ allows end users to avoid in-house maintaining and handling of Caco-2 cell cultures, thus reducing operative costs.
  • The kit has been designed to provide a user-friendly and suitable tool for high-throughput automated procedures.
  • Cacoready ™ provides the 21-day barrier.
  • Cacoready ™ robustness allows testing of poorly water-soluble compounds.
  • Our exclusive shipping medium ensures the stability of barrier properties.
  • Cacoready ™ can be used up to 9 days after its reception, thus enabling flexibility in the design and planning of experimental work.
  • Cacoready ™ has been validated by more than 10 different industrial partners (from Spain, Canada, Japan and France).
  • Cacoready ™ provides a better barrier system than other commercially available products.
  • The kit is produced under quality standards (ISO9001:2000)
  • Cacoready ™ allows customized designs.
  • Cacoready ™ represents a cost-effective choice.

CacoReady™ represents a noticeable innovation, supported by the following main features:

  • It provides users with the differentiated Caco-2 barrier (21-day system), plated on 24-well Transwells.
  • Transwells are integrated, allowing handling much easier.
  • The system is embedded in a special patented conditioning medium, which allows up to 5 days of transportation/storage at room temperature, and also makes the system very user-friendly for handling requirements.
  • Price per plate allows cost saving to research managers.

Product validation: a collaborative approach

The product has been designed and validated in collaboration with industrial partners. Though concrete names will be omitted, most of the data shown in this dossier have been provided to ADVANCELL by several independent biotech and pharmaceutical companies.

This product dossier is intended to define the kit in detail, and to highlight the main advantages of using ADVANCELL’s CacoReady™ system. This document has been organized in the following sections:

Extensions of the CacoReady™ product line

  • CacoReady™-Plus (anti-absorptive for lipophilic compound testing)
  • CacoReady™-HTS (96 transwells-size) (u.d.)
  • CacoCYPC (oral/intestinal bioavailability and metabolism testing in one step) (u.d.)
  • Caco-Goblet (in vitro mucus-secreting intestinal barrier) (u.d)
  • Enhanced solubility cocktail (accessory product)

 

 

 

A Novel, Ready-to-Use System for

In Vitro Intestinal Absorption Evaluations

FEATURES AND Benefits

• Differentiated Caco-2 barrier (21-day system), plated on HTS

Transwell®-96 or HTS Transwell-24 permeable supports.

• Integrated Transwells are to allow easier handling.

• Proprietary conditioning medium allows up to 5 days

of transportation/storage at room temperature.

• User-friendly system and easy handling.

• Cost-effective for any size laboratory.

TECHNICAL DESCRIPTION

The CacoReady™ kit consists of differentiated Caco-2 cell barriers, shipped at day 13 of differentiation. It provides

14-day polarized cultures of Caco-2 cells on polycarbonate microporous filters in HTS Transwell-24 well or Transwell-

96 well plates. The CacoReady™ Kit can be used up to 9 days after its reception. After post-conditioning this

kit provides a 21-day Caco-2 barrier.

The intended use of this kit is for in vitro evaluation of oral absorption efficiency, high-throughput screening of

compounds, oral bioavailability, oral toxicity, mechanisms for oral/intestinal absorption, research on new delivery

systems and others.

Confocal analysis of occludin staining (green)

revealing tight junction status in CacoReady™

cell barrier.

Call toll free: 1-877-ADMEcel for an evaluation today

Capabilities

• Oral absorption efficiency

• Compound screening

• Oral bioavailability

• Mechanisms for oral/intestinal absorption

• Oral toxicity

• Research on new delivery systems

Providing flexibility in designing and planning your experiments

The CacoReady™ kit provides 14-day polarized cultures

of Caco-2 cells on polycarbonate microporous filters in

24- or 96-well plates.

Apical compartment

Basal compartment

Caco-2

monolayer

Microporous filter

Apparent permeability coefficient of standard compounds

Product InformationProduct Number Product Name

001-1001 CacoReady™ 24-well Kit

001-1002 CacoReady™ 96-well Kit

CacoReady is a trademark of Advancell, Transwell is a registered trademark of Corning Life
 

RELATED DOCUMENTS

CacoReady Fact Sheet

CacoReady Fact Sheet
CacoReady Technical Note
CacoReady-24 User Manual
CacoReady-96 User Manual
CacoReady Quick Reference Card
CacoReady References
 

 

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