TRAIL-R1/Fc Chimera

Immunology / Infectious agents / Cellular Biology / Molecular biology / Instruments / Lentiviral Technology / RNAi Libreries / Stem Cell Research / MicroRNA / Proteomics / Chemicals / Campaign / AntibodiesPSA Recombinant Human Vimentin PAG Fc Chimera TRAIL-R1/Fc Chimera TRAIL-R2/Fc Chimera LAB TRAIL-R1/Fc Chimera

Free Live Chat Software

GENTAUR BVBA

VAT BE0473327336

Av. de l Armee 68 B4

1040 Brussels BELGIUM

Tel + 32 16 58 90 45

Fax + 32 16 50 90 45

GENTAUR France SARL

SIRET 48423788800017

Rue Lagrange, 9

75005 Paris, France

Tel 01 43 25 01 50

Fax 01 43 25 01 60

GENTAUR Germany

52074 Aachen, Germany

Tel +32 16 58 90 45

Fax +32 16 50 90 45

GENTAUR Pol Sp. Z.o.o. Ulica Ogarna 15/19B m2

80-826 GDANSK

Tel 00 48 51 760 77 08

Fax: 00 32 16 50 90 45

GENTAUR Italy

23015 Milano, Italy

Tel 02 36 00 65 93

Fax 02 36 00 65 94

Česká republika Praha
+420246019719

Danmark

+4569918806

Finland Helsset
+358942419041

Ελλάς Αθήνα
+302111768494

Ireland Dublin
+35316526556

Luxembourg
+35220880274

Magyarország Budapest
+3619980547

Nederland
+31208080893

Norge Oslo
+4721031366

Österreich
+43720880899

Sverige Stockholm
+46852503438

Schweiz Züri
+41435006251

Northern America

Canada Montreal
+15149077481

US New York
+17185132983

Asia 日本
+81 78 386 0860

Other Countries
0032 (0)16 41 44 07

Recombinant human TRAIL-R1 (DR4/ TNFRSF10A)/Fc Chimera

Source:

Produced in HEK 293 cells. The extracellular domain of human TRAIL-R1 (aa 1 - 238) is fused to the Fc portion of human IgG1.

Description:

DR4 is a transmembrane protein, also called TRAIL receptor 1 (TRAIL-R1). The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.
Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

Applications:

Loading control

Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Example Data:

Fig. 1. SDS-PAGE

Fig.1. SDS-PAGE Electrophoresis of TRAIL-R1 (DR4) / Fc recombinant protein (12% separating gel; reducing conditions).
Lane 1 to 3: TRAIL-R1 (DR4)/ Fc recombinant protein (2000 ng, 1000 ng, 500 ng per lane). Staining with Coomasie Blue.

Fig. 2. Western Blotting

Fig.2. Western Blotting of TRAIL-R1 (DR4) / Fc recombinant protein. Reducing conditions.
Lane 1 to 5: Immunostaining with TRAIL-R1 (DR4) specific antibody DR-4-02 (Cat. No. 10-403-C100; dilution 2 μg/ml ). Detection with Goat anti-mouse / HRP secondary antibody. Amount of TRAIL-R1 (DR4)/ Fc recombinant protein loaded on each lane: (1) 370 ng, (2) 150 ng, (3) 75 ng, (4) 37 ng, (5) 15 ng.

________________________________________________________________________________________________________________________

Lyophilized

RL-001-C050

0.05 mg

390 EUR